A study on alpha-terpineol in Alzheimer’s disease with the use of rodent in vivo model, restraint stress effect and in vitro Amyloid beta fibrils

Alzheimer’s disease (AD) is a neurological disorder in which the neuronal degeneration associated with inflammatory processes and oxidative stress. Since alpha-terpineol was shown to possess antioxidant anti-inflammatory effects, administration of this compound studied on rat model AD. To create model, Aβ1-42 injected into hippocampus male Wistar rats. Generated AD models were divided simple short-term immobilization stress added. Preventive therapeutic (post-AD induction) effects consumption (100 mg/Kg) subsequently investigated models, compared control groups. Biochemical factors (superoxide dismutase malondialdehyde), histological manifestations (amyloid plaques neuron counts) possible memory impairment (shuttle-box experiment) all For vitro experiment, effect checked fibril formation. In preventive modes, could improve neurogenesis long-term while reducing amyloid plaque counts ameliorating biochemical (higher levels superoxide malondialdehyde reduced MDA). vitro, shorter fibrillar structures formed presence alpha-terpineol, indicates an anti-amyloid for compound. conclusion, significantly counteracted consequences.